Safety and Side Effects

PREMARIN has been extensively studied.

PREMARIN offers healthcare professionals flexible dosing options so they can choose the lowest effective dose. It is important that you and your doctor weigh the benefits and risks before starting any treatment.

What is the most important information you should know about PREMARIN?

  • Estrogens increase the chance of getting cancer of the uterus.

    Report any unusual vaginal bleeding right away while you are using these products. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.

  • Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia.

Using estrogens, with or without progestins, may increase your chance of getting heart attacks, strokes, breast cancer, and blood clots. Using estrogens, with or without progestins, may increase your chance of getting dementia, based on a study of women age 65 years or older. You and your healthcare provider should talk regularly about whether you still need treatment with estrogens.

PREMARIN should be used at the lowest effective dose and for the shortest duration consistent with your treatment goals and risks. If you are using or are considering using PREMARIN only to treat your symptoms of vaginal dryness, consider topical therapies first. If you are using or are considering using PREMARIN only to prevent osteoporosis due to menopause, talk with your healthcare professional about whether a different treatment or medicine without estrogens might be better for you.

PREMARIN should not be used if you have unusual vaginal bleeding, have or had cancer of the breast or uterus, had a stroke or heart attack, have or had blood clots or liver problems, are allergic to any of the ingredients in PREMARIN, or think you may be pregnant. In general, the addition of a progestin is recommended for women with a uterus to reduce the chance of getting cancer of the uterus.

In a clinical trial, the most commonly reported (≥5%) side effects that occurred more frequently with PREMARIN than with placebo were vaginitis due to yeast or other causes, vaginal bleeding, painful menstruation, and leg cramps.

PREMARIN (conjugated estrogens tablets, USP) is a prescription treatment used after menopause. PREMARIN is used after menopause to reduce moderate to severe hot flashes; to treat moderate to severe dryness, itching, and burning, in and around the vagina; and to help reduce your chances of getting osteoporosis (thin weak bones).