PREMARIN (conjugated estrogens) is used after menopause to reduce moderate to severe hot flashes.

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ABOUT PREMARIN

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PREMARIN is a treatment for moderate to severe hot flashes due to menopause that has helped generations of women.

Seven or more moderate to severe hot flashes due to menopause a day could mean it's time to take action.

Ask your doctor about clinically proven PREMARIN today.

NEED HELP GETTING STARTED?

Our Hot Flash Discussion Starter can help you track your hot flashes.

PREMARIN AND HOT FLASHES

PROVEN RELIEF FOR MODERATE TO SEVERE
POSTMENOPAUSAL HOT FLASHES.

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PREMARIN has been shown to help reduce the number of moderate to severe hot flashes due to menopause by over 80% at each dose studied* compared to 51% for placebo at 12 weeks.

*Number of patients studied at each dose listed next to each dosage. 0.3 mg (n=30), 0.45 mg (n=32), 0.625 mg (n=27), placebo (n=28).

You may get relief as soon as 4 weeks.

Keep in mind the time it takes to experience relief can be different for different women. In a clinical trial, PREMARIN significantly reduced the number of moderate to severe hot flashes due to menopause, as compared to placebo. Some women started to experience relief as soon as 4 weeks into treatment.

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At all doses studied (0.3 mg, 0.45 mg, and 0.625 mg), women taking PREMARIN experienced significantly fewer moderate to severe hot flashes versus placebo.

Talk to your doctor about whether PREMARIN may be right for you.

PREMARIN should be used at the lowest effective dose and for the shortest length of time consistent with your treatment goals and risks.

SAFETY AND SIDE EFFECTS

WHAT IS THE MOST IMPORTANT INFORMATION YOU SHOULD KNOW ABOUT PREMARIN?

Using estrogen-alone may increase your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using PREMARIN. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.

Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes or dementia (decline in brain function).

Using estrogen-alone may increase your chances of getting strokes or blood clots. Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.

Using estrogens, with or without progestins, may increase your chance of getting dementia, based on a study of women 65 years of age or older.

You and your healthcare provider should talk regularly about whether you still need treatment.

Do Not Take PREMARIN If You:

  • Have unusual vaginal bleeding
  • Have or had certain cancers
  • Had a stroke or heart attack
  • Have or had blood clots or liver problems
  • Have a bleeding disorder
  • Are allergic to PREMARIN or any of its ingredients
  • Think you may be pregnant

ADDITIONAL IMPORTANT INFORMATION:

  • In general, the addition of a progestin is recommended for women with a uterus to reduce the chance of getting cancer of the uterus
  • Estrogens increase the risk of gallbladder disease
  • Discontinue estrogen if loss of vision, pancreatitis, liver problems, severe increase in calcium in the blood, or a severe increase in triglycerides occur
  • If you take thyroid medication, consult your healthcare provider, as use of estrogens may change the amount needed

The most common (≥5%) side effects:

  • Abdominal pain
  • Asthenia
  • Pain
  • Back pain
  • Headache
  • Flatulence
  • Nausea
  • Depression
  • Insomnia
  • Breast pain
  • Endometrial hyperplasia
  • Leucorrhea
  • Vaginal hemorrhage
  • Vaginitis

These are not all of the possible risks and side effects of PREMARIN. For more information, see Important Safety Information below and speak with your doctor.

PREMARIN should be used at the lowest effective dose and for the shortest length of time consistent with your treatment goals and risks. You and your doctor should talk regularly about treatment with PREMARIN.

IMPORTANT SAFETY INFORMATION AND INDICATION

Using estrogen-alone may increase your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using PREMARIN. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.

Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes or dementia (decline in brain function).

Using estrogen-alone may increase your chances of getting strokes or blood clots. Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.

Using estrogens, with or without progestins, may increase your chance of getting dementia, based on a study of women 65 years of age or older.

Estrogens should be used at the lowest dose possible, only for as long as needed. You and your healthcare provider should talk regularly about whether you still need treatment.

PREMARIN should not be used if you have unusual vaginal bleeding, have or had cancer, had a stroke or heart attack, have or had blood clots or liver problems, have a bleeding disorder, are allergic to any of its ingredients, or think you may be pregnant. In general, the addition of a progestin is recommended for women with a uterus to reduce the chance of getting cancer of the uterus.

Estrogens increase the risk of gallbladder disease. Discontinue estrogen if loss of vision, pancreatitis, or liver problems occur. If you take thyroid medication, consult your healthcare provider, as use of estrogens may change the amount needed.

The most common (≥5%) side effects are abdominal pain, asthenia, pain, back pain, headache, flatulence, nausea, depression, insomnia, breast pain, endometrial hyperplasia, leucorrhea, vaginal hemorrhage, and vaginitis.

INDICATION

PREMARIN is used after menopause to reduce moderate to severe hot flashes.

Please see Full Prescribing Information, including BOXED WARNING and Patient Information.

Patients should always ask their doctors for medical advice about adverse events.

You are encouraged to report adverse events related to Pfizer products by calling 1-800-438-1985 (US only). If you prefer, you may contact the US Food and Drug Administration (FDA) directly. Visit http://www.fda.gov/MedWatch or call 1-800-FDA-1088.